THE ANTICONVULSANT ACTIVITY OF CARBAMATE ESTERS OF CERTAIN 2,2-DISUBSTITUTED-1,3-PROPANEDIOLS

¹ Wallace Laboratories, Inc., New Brunswick, New Jersey

The intensity and duration of the anticonvulsant action of some carbamate and cyclic carbonate esters of 2,2-disubstituted-1,3-propanediols to electroshock seizures were tested in mice.

Most monocarbamates had an action of somewhat greater intensity but of equally short durations as the parent compounds. Most dicarbamates were longer acting and had a stronger anticonvulsant action than the corresponding diols. This suggests that these compounds act as such and do not require break-down in the body to the diol to become effective anticonvulsants.

The 5,5-disubstituted-1,3-dioxane-2-one derivatives had a weak and fleeting anticonvulsant action.