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Journal of Pharmacology And Experimental Therapeutics, Vol. 104, Issue 2, 224-228, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

DIPHENHYDRAMINE HYDROCHLORIDE, U.S.P. XIV, AND RESPIRATORY TRACT FLUID

Shirley M. R. Bidwell 1 and Eldon M. Boyd 1

1 Department of Pharmacology, Queen's University, Kingston, Ontario

Diphenhydramine hydrochloride, U.S.P. XIV, was injected subcutaneously into 42 rabbits, 19 cats, 11 guinea pigs and 13 albino rats, in doses of from 1 to 100 mgm. per kgm. body weight, the animals being arranged for the collection of respiratory tract fluid. Used as controls without diphenhydramine hydrochloride, were 16 rabbits, 15 cats, 8 guinea pigs and 15 albino rats.

In none of these experiments did diphenhydramine hydrochloride have any effect upon the rate of volume output, the chloride content, the relative viscosity and the specific gravity of respiratory tract fluid.

Submitted on October 29, 1951






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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.