TOXICOLOGICAL STUDIES OF ORTHOPHENYLPHENOL (DOWICIDE 1)

¹ Division of Pharmacology and Toxicology, University of Rochester School of Medicine and Dentistry, Rochester, New York
² The Biochemical Research Department, The Dow Chemical Company, Midland, Michigan

1. Orthophenylphenol has a low acute oral toxicity for male rats; the LD₅₀ with its 19/20 confidence limits was found to be 2.7 (2.4 to 3.1) gm./kgm.

2. Orthophenylphenol, when tested as a 5.0 per cent solution in sesame oil, and as a 0.1 per cent aqueous solution of the sodium salt on 200 human subjects, failed to cause either primary skins irritation or skin sensitization.

3. Male and female rats (25 of each sex per group) that were maintained for two years on diets containing 0 (control), 0.02, and 0.2 per cent o-phenylphenol showed no adverse effects as judged by growth, mortality, gross appearance, hematology, urinary sugar and proteins values, organ weights, tissue content of o-phenylphenol, and histopathological examination of various tissues. A similar group of rats maintained for two years on a diet containing 2 per cent of the material deviated from the control by exhibiting slight retardation of growth, histological kidney changes (marked tubular dilation), and the presence of small amounts of o-phenylphenol its the kidney tissue.

4. Dogs (two per group) that received oral doses of 0 (control), 0.02, 0.2, and 0.5 gm./kgm./day of o-phenylphenol for a period of one year showed no adverse effects as judged by body weights, gross appearance, hematological values, urinary sugar and protein values, organ weights, and histopathological examination of the various tissues.

This article has been cited by other articles:

				C Timchalk, S Selim, G Sangha, and M J Bartels The pharmacokinetics and metabolism of 14C/13C-labeled ortho-phenylphenol formation following dermal application to human volunteers Human and Experimental Toxicology, August 1, 1998; 17(8): 411 - 417. [Abstract] [PDF]