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Journal of Pharmacology And Experimental Therapeutics, Vol. 104, Issue 1, 76-86, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE EMETIC PROPERTIES OF VERATRUM DERIVATIVES

Edward D. Swiss 1

1 Department of Pharmacology, Boston University School of Medicine

The ED50 values with 19/20 confidence limits for several pure alkaloids and mixtures of veratrum are presented. The high correlation between emetic dose and hypotensive dose has been demonstrated. Irritation of the gastro-intestinal tract has been shown to be an impotent factor in the production of emesis after veratrum administration. The vomiting center in the medulla has been suggested as the site of emetic action of veratrum. Several agents have been shown to be ineffective in the control of emesis induced by intravenous veratrum in the dog.

Submitted on October 8, 1951






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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.