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Journal of Pharmacology And Experimental Therapeutics, Vol. 104, Issue 1, 1-10, 1952
Copyright © 1952 by American Society for Pharmacology and Experimental Therapeutics

THE BIOLOGICAL LIBERATION OF MORPHINE FROM CODEINE IN THE RAT

T. K. Adler 1 and F. H. Shaw 2

1 Division of Pharmacology and Experimental Therapeutics, University of California School of Medicine, San Francisco 22
2 Division of Pharmacology and Experimental Therapeutics, University of California School of Medicine, San Francisco 22, California

Under aerobic conditions, incubation of rat liver slices with Krebs-Ringerbicarbonate to which codeine has been added, results in the disappearance of codeine and the formation of morphine. The liberated morphine is further metabolized by conjugation.

The total amount of morphine formed represents less than one-half the metabolized codeine.

The disappearance of codeine is markedly reduced by the presence of M/1500 mono-iodoacetic acid; the presence of M/50 NaF has no apparent effect on the disappearance of codeine.

A rapid method for the assay of codeine concentration is presented.

Submitted on August 6, 1951




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Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics.