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Journal of Pharmacology And Experimental Therapeutics, Vol. 103, Issue 3, 288-292, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

ANTISPASMODIC AND LOCAL ANESTHETIC ACTIVITY OF DIMETHYLAMINOETHYL SUBSTITUTED COMPOUNDS

John F. Reinhard 1, Eugene T. Kimura 1, and John V. Scudi 1

1 Research Laboratories, Nepera Chemical Company, Inc., Yonkers, New York

Dimethylaminoethyl-substituted compounds were tested for antispasmodic and local anesthetic activity. Seventeen compounds were active against histamine, nine against acetyicholine and five against barium chloride. Eight derivatives blocked both histamine and acetylcholine and two antagonized all three spasmogenic agents. Eight members of the series had more than twenty times the local anesthetic potency of cocaine. Dialkyl-substituted dimethylaminoethylamines are reported as a new class of local anesthetics. Relationships between structure and activity have been discussed.

Submitted on July 30, 1951






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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.