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Journal of Pharmacology And Experimental Therapeutics, Vol. 103, Issue 1, 93-105, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF CORTISONE, DESOXYCORTICOSTERONE, AND ADRENOCORTICOTROPHIC HORMONE UPON THE RESPONSES OF ANIMALS TO ANALGESIC DRUGS

Charles A. Winter 1 and Lars Flataker 1

1 Merck Institute for Therapeutic Research, Rahway, N. J.

1 . Cortisone, ACTH, and DCA were without effect upon the reaction time of the tail-flick response to thermal stimuli in normal rats. Cortisone and ACTH, however, markedly reduced the effect of morphine or methadone upon this reaction, while DCA enhanced it.

2. Cortisone proved to have a synergistic action with the analgesic antagonist, N-allylnormorphine. The steroid reduced the threshold for effectiveness of the antagonist.

3. Cortisone provided partial protection in mice against toxic doses of methadone.

4. Cortisone increased voluntary activity of normal mice, but reduced the hyperactivity of morphinized mice.

5. Cortisone increased the excitatory effect of morphine in cats.

6. Spinal cord section was shown to reduce the reaction time of the tail-flick response in rats when submaximal stimuli were employed. Cortisone and ACTH reduced the effect of morphine on the spinal reflex, while DCA enhanced it.

7. The significance of these observations with respect to the effect of cortisone Upon the C.N.S. is discussed.

Submitted on June 21, 1951




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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.