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Journal of Pharmacology And Experimental Therapeutics, Vol. 103, Issue 1, 74-78, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

RELATIVE HYPOTENSIVE ACTIVITY OF CERTAIN VERATRUM ALKALOIDS

George L. Maison 1, Eleanor Gotz 1, and J. W. Stutzman 2

1 Department of Pharmacology, Boston University School of Medicine
2 Smith Kline and French Laboratories, Philadelphia, Pennsylvania

Fifteen substances derived from veratrum plants have been assayed for their equi-hypotensive dose at 32 per cent fall of mean arterial pressure in anesthetized normotensive dogs. In terms of a standard reference powder derived from Veratrum viride (Veriloid) taken as 1 the following potencies were found: germitrine 11, neogermitrine 8.7, germerine 5.3, protoveratrine 4.7, germidine 2.4, veratridine 0.5, veratrine 0.3, cevadine 0.18, veratramine 0.03. Germine, rubijervine, jervine, isorubijervine and pseudojervine proved so weak that accurate determination of potency was not possible. Dose-response curves are presented which suggest identity of mechanism of hypotensive action of protoveratrine, of veratridine and of mixtures of ester alkaloids.

Submitted on June 18, 1951






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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.