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Journal of Pharmacology And Experimental Therapeutics, Vol. 103, Issue 1, 7-9, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

A METABOLITE OF PAMAQUINE FROM CHICKENS

Edward S. Josephson 1, Joseph Greenberg 1, D. Jane Taylor 1, and H. L. Bami 2

1 Federal Security Agency, Public Health Service, National Institutes of Health, National Microbiological Institute, Laboratory of Tropical Diseases, Bethesda 14, Maryland
2 Malaria Institute of India, Delhi, India

One of the products of pamaquine metabolism following a single oral dose of this drug to chickens is 8-(diethylamino-1-methylbutylamino)-5,6-quinoline-quinone. Proof of structure of this metabolite is based upon its conversion to the quinoxaline following interaction with orthophenylenediamine and comparing the crystalline dipicrate of the resulting product with that obtained from synthetic 8-(diethylamino-1-methylhutylamino)-5,6-quinolinequinone treated in similar fashion.

Submitted on May 14, 1951






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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.