JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chen, G.
Right arrow Articles by Bratton, A. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chen, G.
Right arrow Articles by Bratton, A. C., Jr.
Journal of Pharmacology And Experimental Therapeutics, Vol. 103, Issue 1, 54-61, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

THE ANTICONVULSANT ACTIVITY OF agr-PHENYL SUCCINIMIDES

Graham Chen 1, Ruth Portman 1, Charles R. Ensor 1, and Andrew C. Bratton Jr. 1

1 Parke, Davis and Company, Detroit, Michigan

An appraisal of the anticonvulsant activity has been made of derivatives of agr-phenyl succinimide. The agr,beta-methyl and ethyl substituted compounds were more effective against Metrazol than against electrically-induced convulsions. Methylation of the heterocyclic nitrogen of most of these succinimides resulted in an increase in anti-Metrazol potency. This enhancing effect becomes less with the increasing length and branching of the alkyl chain.

The agr,agr-diphenyl and the agr,beta-diphenyl succinimides on the other hand, were more effective in suppressing electrically-induced than Metrazol-induced convulsions. Methylation of the heterocyclic nitrogen of these compounds diminished their anti-electroshock activity.

Submitted on June 11, 1951






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.