JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Karlsson, J. L.
Right arrow Articles by Elliott, H. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Karlsson, J. L.
Right arrow Articles by Elliott, H. W.
Journal of Pharmacology And Experimental Therapeutics, Vol. 103, Issue 1, 1-6, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

DELAYED ARREST OF RAT BRAIN SLICE RESPIRATION CAUSED BY PENTOBARBITAL DURING THE METABOLISM OF GLUCOSE

J. L. Karlsson 1, V. C. Sutherland 1, and H. W. Elliott 1

1 Division of Pharmacology and Experimental Therapeutics, University of California School of Medicine, San Francisco, 22

Oxidation by rat brain slices of glucose, but not of pyruvate, in the presence of a concentration of pentobarbital capable of producing anesthesia in vivo has been shown to result in a delayed but sudden interference with further oxygen uptake. The effect is definitely linked to the metabolism of glucose, since metabolic arrest of the tissue oxidizing pyruvate is obtained a certain length of time after glucose is also added. Extracellular toxicity or exhaustion of metabolites has been ruled out, so that the metabolic arrest must be caused by phenomena inside the tissue.

Submitted on May 7, 1951






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.