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1 Department of Pharmacology, University of Virginia Medical School, Charlottesville, Virginia
1. The comparative effect of d- and l-methadone on the blood glucose of dogs has been investigated. At a dose of 3 mgm./kgm. the l-methadone increased the blood glucose 43.7 mgm. per cent whereas d-methadone produced an increase of only 12.6 mgm. per cent.
2. Sedative doses of pentobarbital partially inhibited the hyperglycemic response to l-methadone and morphine. Anesthetic doses of pentobarbital completely inhibited l-methadone hyperglycemia.
Submitted on May 18, 1951