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Journal of Pharmacology And Experimental Therapeutics, Vol. 102, Issue 4, 258-260, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

ALKYL NITRITES. XV. THE EFFECT OF NITRITES AND NITRATES ON THE OXYGEN UPTAKE OF ARTERIAL TISSUE

John C. Krantz Jr. 1, C. Jelleff Carr 1, and M. Joyce Knapp 1

1 Department of Pharmacology, School of Medicine, University of Maryland, Baltimore

1. The oxygen uptake of the rat's aorta is inhibited by sodium nitrite in therapeutic concentrations. This does not obtain with sodium nitrate.

2. The vasodilators, erythritol tetranitrate, octyl nitrite and amyl nitrite, do not interfere significantly with the oxygen uptake of arterial tissue in therapeutic levels. Glyceryl trinitrate does inhibit the oxygen uptake of arterial tissue.

3. The relationship between ATPase inhibition, oxygen uptake and vasodilation produced by the drugs of the nitrite-nitrate series is discussed.

Submitted on May 14, 1951






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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.