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Journal of Pharmacology And Experimental Therapeutics, Vol. 102, Issue 4, 250-257, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

EVALUATION OF CERTAIN ANTIHISTAMINICS FOR USE IN AURICULAR FIBRILLATION

Elton L. McCawley 1, George A. Weston 2, and N. A. David 1

1 Department of Pharmacology, University of Oregon Medical School, Portland, Oregon
2 University of Oregon Medical School Research Scholar in Pharmacology

1. The isolated auricle technique of Dawes has been used to study the action of a series of antihistamine compounds on the myocardial refractory period. The antihistaminics studied prolong the refractory period at concentrations lower than that required by quinidine. Diphenhydramine appeared worthy of clinical trial in patients with auricular fibrillation.

2. Fibrillation or "flutter" has been evoked in the isolated auricle preparation by a localized traumatic infarct or by aconitine. Quinidine and diphenhydramine can produce a sudden conversion to a slow rhythm in these preparations.

Submitted on May 11, 1951






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