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Journal of Pharmacology And Experimental Therapeutics, Vol. 102, Issue 4, 215-218, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

ACUTE TOLERANCE TO THIOPENTAL

Bernard B. Brodie 1, Lester C. Mark 1, Eleonore Bernstein 1, E. M. Papper 1, and Philip A. Lief 2

1 Section on Chemical Pharmacology, National Heart Institute, National Institutes of Health, U.S. Public Health Service, Federal Security Agency, Bethesda, Md. and Research Service, New York University, Goldwater Memorial Hospital, and Department of Anesthesiology, New York University Medical Center, and Department of Surgery (Anesthesiology), College of Physicians and Surgeons, New York City
2 Montefiore Hospital, New York City

After a large dose of thiopental, human subjects awake at plasma levels that are considerably higher than those occurring after smaller doses. This tolerance is probably a tissue adaptation to the effects of the drug.

Submitted on April 26, 1951




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