BENEMID, p-(DI-n-PROPYLSULFAMYL)-BENZOIC ACID: TOXICOLOGIC PROPERTIES

¹ Pharmacology Section, Research Division, Sharp & Dohme, Inc., Glenolden, Pa.

The acute and chronic toxicity of Benemid, p-(di-n-propylsulfamyl)-benzoic acid, was studied in mice, rats, dogs, rabbits and guinea pigs.

The acute toxicity signs were thought to be of central nervous system origin. Deaths were apparently due to respiratory arrest during tonic convulsions. The values of the LD₅₀'s in different animals when Benemid was given by intravenous, subcutaneous, intraperitoneal or oral routes indicated that the drug was well absorbed by all routes and that the toxicity for the different species of animals was similar.

Daily oral administration of Benemid to six dogs for eight weeks in dosages as high as 200 mgm./kgm. and to 56 rats for twelve weeks in dosages as high as 400 mgm./kgm. did not cause changes in hematologic values that could be attributed directly to the drug. Chemical studies of the plasma and urine of the dogs did not reveal significant changes from the control values.

Drug sensitivity tests in guinea pigs failed to produce local or generalized reactions to Benemid.

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