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*PROCAINE
Journal of Pharmacology And Experimental Therapeutics, Vol. 102, Issue 3, 200-207, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

THE INFLUENCE OF PROCAINE AND SOME RELATED COMPOUNDS UPON EXPERIMENTAL AURICULAR FLUTTER IN THE DOG

Barbara B. Brown 1 and George H. Acheson 2

1 Wm. S. Merrell Co., Amity Road, Cincinnati 15, Ohio
2 Department of Pharmacology, University of Cincinnati College of Medicine, Cincinnati, Ohio

Auricular flutter was established by the method of Rosenblueth and Garcia Ramos.

1. Stimulation of the vagus or of the sympathetic innervation accelerates flutter. The effects of section of these nerves suggests a tonic discharge in both sets.

2. Diethylaminoethanol (8 to 64 mgm./kgm.) and diethylaminoethyl 2,4-dichlorobenzoate (0.5 to 8 mgm./kgm.) slow both auricular and ventricular rates and often abolish the auricular flutter. These effects are the same in innervated or decentralized hearts.

3. When the innervation has been sectioned, the effects of procaine (0.5 to 8 mgm./kgm.) are like those described in 2. In the presence of intact innervation, however, the auricular deceleration is more marked, the ventricular rate is accelerated, and the incidence of reversion to sinus rhythm is decreased.

4. Procaine blocks the effects of vagal stimulation upon auricular and ventricular rates. This action is absent in the case of diethylaminoethyl 2,4-dichlorobenzoate.

Submitted on April 6, 1951






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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.