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Journal of Pharmacology And Experimental Therapeutics, Vol. 102, Issue 3, 156-164, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

THE HEPARIN-LIKE ACTIVITY OF A NEW ANTICOAGULANT, TREBURON

Carmen N. Mangieri 1, Recha Engelberg 1, and Lowell O. Randall 1

1 Pharmacology Department, Hoffmann-La Roche Inc., Nutley 10, N. J.

Treburon is a new synthetic anticoagulant which is a sulfated polygalacturonic acid methyl ester methyl glycoside. Treburon has an anticoagulant activity about one-fourth to one-half that of heparin by intravenous and intramuscular routes. By in vitro tests, the activity is about one-fourth that of heparin. The toxicity is about one-half that of heparin. The safety margin is, therefore, at least one-half and possibly equal to that of heparin. Like heparin, it is primarily an antithrombin substance. The anticoagulant can be neutralized by protamine sulfate. Like heparin, it is partially excreted in the urine. It has only a slight effect on prothrombin time and does not affect platelets, fibrinogen or sedimentation rates. In subacute toxicity tests, repeated administration of Treburon did not adversely affect the growth and the blood picture and did not produce spontaneous hemorrhages.

Submitted on March 9, 1951




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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.