JPET Introducing ALZET?ew Model 2006 Pump

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Journal of Pharmacology And Experimental Therapeutics, Vol. 102, Issue 2, 98-102, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE METABOLISM OF PARA-AMINOBENZOIC ACID

Celia White Tabor 1, Marion V. Freeman 1, Judith Baily 1, and Paul K. Smith 1

1 Department of Pharmacology, The George Washington University School of Medicine, Washington, D. C.

Para-aminobenzoic acid is rapidly absorbed and excreted. In the rat the concentrations in the plasma are appreciably higher than in brain, muscle and erythrocytes.

In normal man very little of the drug is excreted as free PABA and only a small amount is excreted as acetylated PABA. Most of it is excreted either as a conjugation product with glycine (p-aminohippuric acid) or as the glucuronate. A small amount of the glucuronate derivative is also acetylated.

Submitted on February 23, 1951






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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.