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Journal of Pharmacology And Experimental Therapeutics, Vol. 102, Issue 2, 94-97, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF THE ADMINISTRATION OF CARBON TETRACHLORIDE TO RATS ON CERTAIN REACTIONS OF THE LIVER IN VITRO

Melissa L. Richter 1

1 Department of Physiology and Pharmacology, Duke University School of Medicine, Durham, North Carolina

1. The livers of rats given CCl4 24 hours previously show less ability to methylate nicotinamide and guanidoacetic acid, form urea from ammonium sulfate in the presence of ornithine, hydroxylate phenylalanine and conjugate morphine than livers from normal animals.

2. The oxygen uptake of slices, the succinoxidase and choline oxidase activity, and the organic phosphates in CCl4-treated livers are higher than normal.

3. The significance of these results is discussed.

Submitted on February 13, 1951






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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.