PROTECTION AGAINST EXPERIMENTAL BERYLLIUM POISONING BY AURIN TRICARBOXYLIC ACID

¹ Division of Biological and Medical Research, Argonne National Laboratory, Chicago, Illinois

1. Aurin tricarboxylic acid, given intravenously in the form of the ammonium salt, markedly increased the survival of mice given an intravenous LD₉₅ of beryllium sulfate (0.7 mgm. Be per kgm.).

2. Rats acutely poisoned with Be were similarly protected.

3. ATA was effective when administered from one hour before to at least eight hours after the injection of Be, and in doses from 1 to 4 mgm. per mouse. Partial protection was given when it was administered 52 hours prior to Be, but none when given sixteen hours after Be.

4. Partial protection was afforded mice given up to 1.0 mgm. of Be per kgm.

5. Repeated small doses of aurin tricarboxylic acid, begun one hour after Be injection and continued at one- or two-day intervals, did not increase survival in mice. Oral administration of a 0.5 per cent solution in drinking water was also ineffective.