THE PHARMACOLOGY OF THE MONO METHYL ETHERS OF MONO-, DI-, AND TRIPROPYLENE GLYCOL IN THE DOG WITH OBSERVATIONS ON THE AURICULAR FIBRILLATION PRODUCED BY THESE COMPOUNDS

¹ Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan

1. Three mono methyl ether derivatives of mono-, di-, and tripropylene glycol have been studied in the dog and found to be central nervous system and cardiac depressants of low toxicity. Death in the intact animal results from respiratory failure.

2. In the anesthetized, artificially respired dog appropriate intravenous doses of these compounds quite consistently produce auricular fibrillation.

3. Auricular anoxia, depressed conduction and heart block with ventricular asystole, and increased intra-auricular pressure all appear to be important factors in the production of this arrythmia.