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Journal of Pharmacology And Experimental Therapeutics, Vol. 102, Issue 2, 138-143, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

COMBINED ACTION OF CARDIOTOXIC DRUGS: A STUDY ON THE ACUTE TOXICITY OF COMBINED QUINIDINE, MEPERIDINE, PENTOBARBITAL, PROCAINE AND PROCAINE AMIDE

B. Calesnick 1, N. H. Smith 1, and R. Beutner 1

1 Department of Pharmacology, Hahnemann Medical College, Philadelphia 2, Pennsylvania

We have demonstrated synergism of acute toxicity when quinidine, meperidine and procaine were used in combination. The possible mode of action has been explored and the potential hazard of cardiotoxicity discussed especially when pentobarbital is also used.

Submitted on March 14, 1951






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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.