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Journal of Pharmacology And Experimental Therapeutics, Vol. 102, Issue 2, 132-137, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

STUDY OF DRUG ACTION ON MAMMALIAN CILIATED EPITHELIUM

John V. Scudi 1, Eugene T. Kimura 1, and John F. Reinhard 1

1 Research Laboratories of the Nepera Chemical Company, Inc., Yonkers, New York

A laboratory method for the quantitative study of drug action on ciliated epithelium has been described. Results obtained with typical vasoconstrictor, antihistaminic and antibacterial drugs are presented. Substances implicated in the allergic state appear to have no direct action on isolated mammalian cilia.

A parallelism between cellular irritation and loss of ciliary motility has been observed. It is suggested that changes in membrane permeability lead to the extrusion of viscid globoid bodies which in turn prevent ciliary motion.

Submitted on March 12, 1951




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J. F. Reinhard, E. T. Kimura, and R. J. Schachter
Some Pharmacologic Characteristics of Isonicotinyl Hydrazide (Pyricidin(R)), A New Antituberculosis Drug
Science, August 15, 1952; 116(3007): 166 - 167.
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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.