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Journal of Pharmacology And Experimental Therapeutics, Vol. 102, Issue 1, 50-54, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF TOPICALLY APPLIED ADRENERGIC BLOCKING AGENTS UPON THE PERIPHERAL VASCULAR SYSTEM

Thomas J. Haley 1 and Margaret Andem 1

1 School of Medicine, University of California at Los Angeles

The peripheral vascular effects of eleven adrenergic blocking agents have been investigated on the rat mesoappendix preparation. Vasoconstrictor, adrenergic blocking and antihistaminic actions have been observed after direct application of these drugs to the capillary bed. It has been demonstrated that the site of these actions is the precapillary sphincters and the terminal arterioles.

Submitted on January 2, 1951




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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.