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Journal of Pharmacology And Experimental Therapeutics, Vol. 102, Issue 1, 31-49, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

FACTORS INFLUENCING FLUOROACETATE POISONING

Practical Treatment with Glycerol Monoacetate

Maynard B. Chenoweth 1, Alexander Kandel 1, Linares B. Johnson 1, and Donald R. Bennett 1

1 Department of Pharmacology, University of Michigan, Ann Arbor, Michigan

1. The ability of various chemical substances to prevent or reverse the toxic effects of sodium fluoroacetate has been studied in mice, rats, rabbits, dogs and rhesus monkeys (Macacca mulatta).

2. Commercially available monoacetin containing about 60 per cent glycerol monoacetate has been found to be superior to any other substance yet tested for general use against fluoroacetate poisoning. Certain characteristics of its action have been described.

3. Various factors such as water and electrolyte imbalance have been assigned distinct, but minor roles in the development of the phenomena of fluoroacetate poisoning.

4. The ability of fluoroacetate to potentiate the depressant action of barbiturates has been observed and the autoprotective effect in rats has been further clarified.

5. An outline has been presented, based upon experiments with monkeys, which may be helpful for the guidance of those treating human fluoroacetate poisoning.

Submitted on December 26, 1950




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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.