JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bovet, D.
Right arrow Articles by Longo, V. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bovet, D.
Right arrow Articles by Longo, V. G.
Journal of Pharmacology And Experimental Therapeutics, Vol. 102, Issue 1, 22-30, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION ON NICOTINE-INDUCED TREMORS OF SUBSTANCES EFFECTIVE IN PARKINSONISM

D. Bovet 1 and V. G. Longo 1

1 Laboratorio di Chimica Terapeutica dell'Istituto Superiore di Sanita, Rome, Italy

1. It has been found that there is a parallelism between the antagonism of some drugs (Diparcol, Panparnit, Artane) against the tremors produced by nicotine, and the satisfactory clinical results obtained with these drugs in the symptomatic therapy of Parkinson's disease.

2. Other drugs, such as Benadryl, Phenergan, Trasentine and amphetamine show the same central antagonistic effect; they are also effective in the clinical treatment of Parkinsonism. This effect seems not to be connected with antihistaminic, spasmolytic, sympathomimetic or anesthetic properties.

3. The comparison between five preparations of similar chemical composition derived from dibenzoparathiazine has afforded proof of a complete similarity between the antagonism that the drugs show to the central effects of nicotine and their usefulness in the treatment of Parkinson's disease.

4. Tetraethylammonium bromide and pentamethylenebistrimethylammonium iodide, which antagonize the peripheral action of nicotine, do not antagonize the tremors induced by nicotine.

5. The results are discussed with respect to the mechanism of action of drugs useful in the treatment of Parkinson's disease.

Submitted on December 20, 1950




This article has been cited by other articles:


Home page
 Arch Intern MedHome page
A. C. ENGLAND Jr. and R. S. SCHWAB
The Management of Parkinson's Disease
Arch Intern Med, September 1, 1959; 104(3): 439 - 468.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.