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Journal of Pharmacology And Experimental Therapeutics, Vol. 102, Issue 1, 16-21, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

ALKYL NITRITES. XIV. THE EFFECT OF NITRITES AND NITRATES ON ARTERIAL ADENOSINE TRIPHOSPHATASE

John C. Krantz Jr. 1, C. Jelleff Carr 1, and Harold H. Bryant 1

1 Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, Md.

1. The ATPase activity of the aorta of the rabbit is inhibited by the rapidly-acting vasodilators such as amyl nitrite, glyceryl trinitrate and isobutylglycollate nitrate.

2. The ATPase activity of the aorta of the rabbit is not inhibited by sodium nitrite.

3. The ATPase activity of the smooth muscle from the uterus or from skeletal muscle is not inhibited by these vasodilators.

4. The relationship of the ATPase action and vasodilation is discussed.

Submitted on December 20, 1950




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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.