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Journal of Pharmacology And Experimental Therapeutics, Vol. 102, Issue 1, 1-4, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

THE RELATIONSHIP BETWEEN CHOLINESTERASE ACTIVITY AND BRAIN PERMEABILITY

Margaret E. Greig 1 and Thomas C. Mayberry 1

1 Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

The administration of physostigmine to mice prior to intravenous injection of either barbital or glucochloralose has been found to reduce the anesthetic lag by about 50 per cent. In the case of barbital, this is accompanied by an increase in the rate of penetration of the drug into the brain.

This increased permeability of the brain to the anesthetic is attributed to inhibition of cholinesterase activity by physostigmine.

Submitted on December 18, 1950






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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.