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Journal of Pharmacology And Experimental Therapeutics, Vol. 101, Issue 4, 362-367, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE MECHANISM BY WHICH SULFADIAZINE AFFECTS THE SURVIVAL OF THE MAMMALIAN EMBRYO

Allan D. Bass 1, Chester L. Yntema 1, Warner S. Hammond 1, and Marjorie L. Frazer 1

1 Departments of Pharmacology and Anatomy, College of Medicine, Syracuse University, Syracuse, New York

1. It has been shown that SAD and SAM reduce the percentage of deliveries when administered to pregnant mice. This effect is obtained when these agents are administered prior to the eighth day of gestation.

2. This effect of sulfadiazine on the pregnancy is not counteracted by nicotinamide or folic acid.

3. Evidence is presented which suggests that high blood concentrations of sulfadiazine interfere in some way with the production or utilization of either the female sex hormones or the gonadotrophic hormones.

4. Lithium chloride and nitrogen mustard also reduce the percentage of deliveries.

Submitted on December 13, 1950






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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.