JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Craver, B. N.
Right arrow Articles by Smith, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Craver, B. N.
Right arrow Articles by Smith, J.
Journal of Pharmacology And Experimental Therapeutics, Vol. 101, Issue 4, 353-361, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

SOME PHARMACOLOGIC PROPERTIES OF m-TOLYLOXY-ACETAMIDINE HYDROCHLORIDE, A CARDIOTONIC DRUG

Bradford N. Craver 1, Anne Cameron 1, and James Smith 1

1 Research Department, Division of Macrobiology, Utha Pharmaceutical Products, Inc., Summit, New Jersey

1. Certain pharmacological properties have been presented of m-tolyloxy-acetamidine hydrochloride, a substance with marked positive inotropic and chronotropic effects upon the heart-lung preparation and upon the isolated, perfused hearts of some but not all of the five species studied.

2. The mechanism of action is presumably histaminic, since it could be antagonized by the same doses of tripelennamine required to antagonize the effects of histamine and was not influenced by doses of procaine hydrochloride and atropine sulfate comparable in activity to the local anesthetic and parasympatholytic actions, respectively, of tripelennamine.

3. The results would appear not to support the concept of competitive inhibition between histamine and antihistaminics for the same "receptor substance".

Submitted on November 30, 1950






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.