JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maren, T. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maren, T. H.
Journal of Pharmacology And Experimental Therapeutics, Vol. 101, Issue 3, 313-316, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

AN ESTIMATION OF THE ANTIPYRETIC ACTIVITY OF CINCHONINIC ACID DERIVATIVES

Thomas H. Maren 1

1 Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University School of Medicine, Baltimore

1. 3-Hydroxy-2-phenylcinchoninic acid (HPC) produced marked antipyresis in the fevered dog, rabbit and rat.

2. Seven derivatives of cinchoninic acid (those with a 3-OH or 2-Ph substituent) were found to have antipyretic activity in the yeast fevered rat. Of these, the most active was 3-hydroxy-2-phenylquinoline-4,8-dicarboxylic acid. Several compounds, including HPC, were considerably more active than salicylic acid or cinchophen.

Submitted on November 20, 1950






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.