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Journal of Pharmacology And Experimental Therapeutics, Vol. 101, Issue 3, 310-312, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

ROLE OF VAGUS NERVES IN DEPRESSOR ACTION OF VERATRUM DERIVATIVES

J. W. Stutzman 1, Hope Simon 1, and George L. Maison 1

1 Department of Pharmacology, Boston University School of Medicine, Boston, Mass.

Bilateral cervical vagotomy in ten anesthetized dogs did not alter quantitatively the hypotension resulting from intravenous infusions of ester alkaloids of veratrum. Germitrine, protoveratrine, germidine, germerine and veratridine were tested. The alkamine, veratramine, produced the same result. The ten-minute infusions of these agents caused average decreases in mean arterial blood pressure of 25 to 45 per cent.

Submitted on November 20, 1950






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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.