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Journal of Pharmacology And Experimental Therapeutics, Vol. 101, Issue 3, 287-295, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

THE METABOLISM OF THE HEART IN RELATION TO DRUG ACTION

VI. Metabolic Actions of Quinidine on Rat Heart Muscle

J. Leyden Webb 1, Paul R. Saunders 1, and Kazuko Nakamura 1

1 Department of Pharmacology and Toxicology, School of Medicine, University of Southern California, Los Angeles, California

1. Quinidine depressed the endogenous oxygen uptake of rat auricles and ventricle slices at concentrations (1 x 10-4 M and 3 x 10-4 M) which increased the refractory period of isolated auricles and depressed the mechanical activity of ventricle strips.

2. The anaerobic glycolysis of ventricle slices was markedly inhibited at a quinidine concentration of 3 x 10-4 M.

3. Quinidine did not affect appreciably the added oxygen uptake of ventricle slices due to pyruvate, lactate, succinate, malate, or glucose.

4. The effect of quinidine upon the adenosinetriphosphatase activity of ventricle homogenates was investigated.

5. It is believed that a depression of oxidative metabolism is at least partially responsible for the observed pharmacological actions of quinidine upon heart muscle.

Submitted on November 13, 1950






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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.