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Journal of Pharmacology And Experimental Therapeutics, Vol. 101, Issue 3, 259-267, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

SOME ASPECTS OF THE METABOLISM OF CODEINE IN THE RAT

Mark E. Latham 1 and Henry W. Elliott 1

1 Division of Pharmacology and Experimental Therapeutics, University of California School of Medicine, San Francisco 22

1. A distribution study on rats with C14-methoxy-labeled radio-codeine indicated demethylation at the 3-position with the evolution of C*O2 in the expired air.

2. Codeine is excreted unchanged by the kidney and into the lumen of the gastro-intestinal tract.

3. The liver metabolizes codeine to a material with solubility characteristics different from codeine. This material is excreted into the duodenum via the biliary tract.

Submitted on October 30, 1950




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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.