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Journal of Pharmacology And Experimental Therapeutics, Vol. 101, Issue 2, 237-242, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF DFP ON THE CONVULSANT DOSE OF THEOPHYLLINE, THEOPHYLLINE-ETHYLENEDIAMINE AND 8-CHLOROTHEOPHYLLINE

R. J. Johns 1, P. D. Bales 1, and H. E. Himwich 1

1 Medical Division, Army Chemical Center, Maryland

1. Theophylline and theophylline-ethylenediamine produce cortical seizures in dosages which are comparable on a basis of theophylline content.

2. The amount of theophylline and theophylline-ethylenediamine required to produce cortical seizures was reduced to one-sixth by the prior administration of DFP.

3. In most cases (and possibly in all cases) this synergism was not due to the anti-cholinesterase activity of the theophylline-ethylenediamine.

4. Theophylline and theophylline-ethylenediamine are not recommended in the treatment of bronchospasm produced by anticholinesterase poisoning because of the danger of precipitating convulsions. The data were obtained in rabbits and may apply to man as well.

5. 8-Chlorotheophylline did not produce cortical seizures.

6. After subconvulsant doses of DFP, 8-chlorotheophylline still failed to produce seizures in nine out of ten experiments.

Submitted on November 27, 1950






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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.