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*COCAINE
Journal of Pharmacology And Experimental Therapeutics, Vol. 101, Issue 2, 188-199, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

THE ESTIMATION OF AMINES IN BIOLOGICAL MATERIALS WITH CRITICAL DATA FOR COCAINE AND MESCALINE

L. A. Woods 1, J. Cochin 1, E. J. Fornefeld 1, F. G. McMahon 1, and M. H. Seevers 1

1 Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan

1. A general method of estimation of alicyclic and aliphatic amines in plasma, whole blood, urine and tissue with specific reference to cocaine and mescaline has been described.

2. The importance of the type of shaking for extraction of amines from biological material has been discussed.

3. The procedure for mescaline and cocaine has been shown to be specific.

4. Only halogenated sulfonephthalein dyes may be used for color development which is apparently dependent upon quininoid formation from the dye.

5. Investigation of numerous amines indicates that the method has wide application and that color formation is inversely proportional to the molecular weight of the amine.

6. Chloroform appears to be the most convenient solvent to use although preliminary experiments indicate that methylene dichloride, methylchloroform, anisole, bromobenzene, chlorobenzene, toluene and benzene might be employed depending upon the amine, etc.

Submitted on October 30, 1950




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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.