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Journal of Pharmacology And Experimental Therapeutics, Vol. 101, Issue 2, 176-180, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

THE ROLE OF THORACIC SYMPATHETIC PATHWAYS IN THE INDUCTION OF VENTRICULAR ECTOPIC RHYTHMS BY EPINEPHRINE AND CYCLOPROPANE

Carl C. Gruhzit 1, Barbara R. Rennick 2, Gordon K. Moe 2, and Efrain G. Pardo 3

1 Department of Pharmacology, University of Michigan, Ann Arbor
2 Department of Physiology, State University of New York, Medical Center at Syracuse, New York
3 Universidad Nacional Autonoma de Mexico

1. The threshold dose of epinephrine necessary to provoke idioventricular rhythms in dogs under eyelopropane anesthesia was found to be increased slightly by tetraethylammonium chloride or by thoracic sympathectomy.

2. When such "protection" occurred, a reduction in the peak pressor response to epinephrine was always observed.

3. Infusion of blood or constriction of the aorta to a degree which restored the original arterial pressure in all cases restored the original cardiac sensitivity to epinephrine. It was concluded that the cardiac sympathetic innervation participates to no more than a minor extent in the induction of ectopic rhythms by epinephiine and cyclopropane.

Submitted on October 20, 1950






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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.