JPET Celsis microsomes equal better data

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Journal of Pharmacology And Experimental Therapeutics, Vol. 101, Issue 2, 167-175, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

CHEMICAL CORRELATIVES OF DIGITALIS POTENCY IN MAN, CAT AND PIGEON

Louis J. Sciarini 1 and William T. Salter 1

1 Laboratories of Pharmacology and Toxicology, Yale University School of Medicine, New Haven, Connecticut

After suitable fractionation, the digitoxin in samples of Digitalis purpurea tincture has been estimated by a fluorometric procedure. Among five preparations so studied, the estimated digitoxin agreed well with the oral potency in man determined by Dr. Harry Gold. The chemical values varied between 10 and 19 per cent of the intravenous lethal equivalent in cat or pigeon. Because the digitoxin content of powdered digitalis leaf is not constant, the intravenous lethal dose in animals is a poor index of its oral potency in man.

Submitted on October 19, 1950






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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.