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Journal of Pharmacology And Experimental Therapeutics, Vol. 101, Issue 2, 153-155, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

THE RENAL HEMODYNAMIC EFFECTS OF PHENYLEPHRINE (NEOSYNEPHRINE) HYDROCHLORIDE IN MAN

Archer P. Crosley Jr. 1, John K. Clark 1, and Harold G. Barker 1

1 University of Pennsylvania School of Medicine and Hospital, Philadelphia, Pennsylvania

1. In five normotensive human subjects, the pressor effect and bradycardia of phenylephrine (Neosynephrine) administration were associated with a decreased renal blood flow.

2. This decrease in blood flow, due to increased renal resistance located chiefly in the efferent arteriole, was associated with an increased filtration fraction and a relatively unchanged glomerular filtration rate.

Submitted on October 4, 1950






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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.