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Journal of Pharmacology And Experimental Therapeutics, Vol. 101, Issue 2, 125-131, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

CERTAIN ASPECTS OF THE VASOPRESSOR ACTION OF PILOCARPINE

Mary A. Root 1

1 Pharmacology Division, The Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana

In cats a continuous infusion of tetraethylammonium ion converted the usual depressor response to intravenous administration of pilocarpine to a marked pressor response. This pressor response was unaffected by adrenalectomy, evisceration, or kidney ligation. The vasopressor action was blocked or inhibited by previous administration of atropine or of the adrenergic blocking agents, ergotoxine, Dibenamine, and C-7337.

Submitted on September 27, 1950




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