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Journal of Pharmacology And Experimental Therapeutics, Vol. 101, Issue 2, 119-124, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

SALICYLAMIDE: PHARMACOLOGY, FATE AND CLINICAL USE

Manuel Litter 1, Anibal Ruiz Moreno 1, and Leon Donin 1

1 Anti-Rheumatic Center, Faculty of Medicine, University of Buenos Aires, Argentina Research Laboratories, M. Bruel and Co., Buenos Aires, Argentina

1. Salicylamide differs from salicylate in that it produces depression of the central nervous system and smooth muscle, at least as seen in laboratory animals.

2. The drug produces a decrease in prothrombin time instead of the increase produced by salicylates.

3. Salicylamide appears to be useful in rheumatoid conditions and is better tolerated than salicylates. However, as in all instances of newly introduced drugs in the treatment of disease, more study will be required before it can assume its final place in the therapeutic armamentarium.






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Copyright © 1951 by the American Society for Pharmacology and Experimental Therapeutics.