JPET Introducing ALZET?ew Model 2006 Pump

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Journal of Pharmacology And Experimental Therapeutics, Vol. 101, Issue 1, 107-111, 1951
Copyright © 1951 by American Society for Pharmacology and Experimental Therapeutics

THE PULMONARY ARTERIAL PRESSOR EFFECT OF CERTAIN SULFHYDRYL INHIBITORS

Carl C. Gruhzit 1, Braulio Peralta 1, and Gordon K. MOE 1

1 Department of Pharmacology, University of Michigan, Ann Arbor

1. The intravenous administration of alloxan, ANTU, iodoacetamide and oxophenarsine produces an increase in pulmonary arterial pressure due to increased resistance in the pulmonary vascular bed. Tachyphylaxis occurs on repeated injections of ANTU, iodoacetamide and oxophenarsine.

2. The increased pressure in the pulmonary vascular bed plays no obvious oontributory role in the production of edema by these compounds, but it is suggested that both effects may result from capillary damage.

3. The rise in pulmonary arterial pressure produced by the continuous infusion of alloxan is inhibited by 1-thiosorbitol and 2,3-dimercaptopropanol.

Submitted on September 22, 1950






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