JPET Celsis microsomes equal better data

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*PAPAVERINE HYDROCHLORIDE
Journal of Pharmacology And Experimental Therapeutics, Vol. 100, Issue 4, 482-488, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

RELATIVE EXPERIMENTAL CORONARY VASODILATOR POTENCIES OF PAPAVERINE AND ITS ETHYL ANALOGUE, ETHAVERINE (DIQUINOL, PERPARIN)

Claude V. Winder 1, Richard W. Thomas 1, and Oliver Kamm 1

1 The Research Laboratories, Parke, Davis and Company, Detroit, Michigan

The ethyl analogue of papaverine (ethaverine) is on the average equal to papaverine in peak potency as a coronary vasodilator in the surviving rabbit heart, when injected quickly. Its action is more durable at suprathreshold dosage so that in total effect summed over time it is more effective.

Submitted on August 11, 1950






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Copyright © 1950 by the American Society for Pharmacology and Experimental Therapeutics.