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Journal of Pharmacology And Experimental Therapeutics, Vol. 100, Issue 4, 393-397, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF SEVERAL NEW ANTIHISTAMINIC DRUGS UPON THE MAMMALIAN CAPILLARY BED

Thomas J. Haley 1 and Margaret R. Andem 1

1 School of Medkine, University of California at Los Angeles

1. Fifteen new antihistaminic drugs have been evaluated for their ability to cause closure of the precapillary sphincters of the mammalian capillary bed. Anthallan, chloroprophenpyridamine, 194-A, 194-C and Antergan were the most potent local vasoconstrictors tested by this method.

2. The vasoconstrictor effect produced by topical application of the anti-histaminics to the capillary bed was produced at concentrations which were of the same order of magnitude as those obtained in animals or humans after oral or intravenous administration.

3. The relationship between vasoconstrictor activity and chemical structure was discussed.

Submitted on July 31, 1950




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