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Journal of Pharmacology And Experimental Therapeutics, Vol. 100, Issue 3, 346-350, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

THE DIGITALIS-LIKE ACTION OF CRYPTOGRAXDOSIDE A AND B

K. K. Chen 1, Robert C. Anderson 1, and Francis C. Henderson 1

1 Lilly Research Laboratories, Indianapolis 6, Indiana

1. The leaves and stems of Cryptostegia grandiflora, or rubber vine, have a digitalis-like action due to the presence of at least two glycosides, cryptograndoside A and B, both being derivatives of oleandrigenin. The leaves have more than two and one-half times the activity of the sterns.

2. The latex of C. grandiflora is apparently free from digitalis-like substances.

3. Of the two glycosides, cryptograndoside A, a monoside, is more than twice as potent in cats as cryptograndoside B, a bioside.

Submitted on July 17, 1950






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