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Journal of Pharmacology And Experimental Therapeutics, Vol. 100, Issue 3, 316-324, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF 2,2-DIETHYL 1,3-PROPANEDIOL (A NEW ANTICONVULSANT) ON SPINAL CORD REFLEXES

Irwin H. Slater 1, John F. O'Leary 1, and Daniel E. Leary 1

1 Division of Orthopaedic Surgery Department of Surgery, and the Division of Pharmacology and Toxicology, Department of Radiation Biology, of the University of Rochester School of Medicine and Dentistry, Rochester, N. Y.

1. The action of 2,2-diethyl 1,3-propanediol, a compound structurally related to mephenesin, has been examined in mice, rats, rabbits and cats.

2. Observations demonstrating the effectiveness of the drug as an anticonvulsant against Metrazol, strychnine and electric shock have been described.

3. It has been shown that diethyl propanediol depresses the flexion and crossed extension reflexes in both intact anesthetized and in unanesthetized spinal cats without exerting any marked effect upon the normal knee jerk. These findings have been considered as evidence consistent with a selective depression of multisynaptic neurone arcs in the spinal cord.

Submitted on July 12, 1950






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