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Journal of Pharmacology And Experimental Therapeutics, Vol. 100, Issue 3, 273-283, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

THE ENZYMATIC MECHANISM OF BARBITURATE ACTION

H. Persky 1, M. S. Goldstein 1, and R. Levine 1

1 Institute for Psychosomatic and Psychiatric Research and Training and the Department of Metabolic and Endocrine Research, Medical Research Institute, Michael Reese Hospital, Chicago, Illinois

The effect of pentobarbital sodium on a variety of enzyme systems has been studied. The barbiturate is shown to block the pyruvic acid oxidase system, most likely at the oxidation of the two-carbon fragment. The barbiturate does not block the oxidation of flavoprotein by either oxygen or cytochrome c. Rather, the essential sulfhydril groups of the dehydrogenase of the pyruvic acid system are shown to be the barbiturate-sensitive step. The relation of this enzyme inhibition to narcosis in vivo is discussed.

Submitted on July 5, 1950






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