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Journal of Pharmacology And Experimental Therapeutics, Vol. 100, Issue 2, 151-157, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

A COMPARISON OF THE ANTICONVULSANT ACTIONS OF SOME PHENYLHYDANTOINS AND THEIR CORRESPONDING PHENYLACETYLUREAS

Ewart A. Swinyard 1 and James E. P. Toman 1

1 Departments of Pharmacy, Pharmacology and Physiology, University of Utah College of Pharmacy and College of Medicine, Salt Lake City

1. A series of 5-phenyl, 5-R-hydantoins and related phenyl-R-acetylureas have been compared with respect to: (a) aqueous solubility; (b) minimal neurological toxic dose in rats; (c) ability to modify maximal electroshock seizure pattern in rats; (d) anti-Metrazol potency in rats; (e) ability to suppress induced hyperexcitability and hyperresponsiveness in frog sciatic nerve.

2. The data obtained indicate: (a) that all compounds showed some anti-convulsant potency except for the very insoluble diphenylacetylurea, and (b) that there is no close correlation between solubility, anti-electroshock potency, anti-Metrazol potency, and effects on peripheral nerve.

3. A comparison of potencies suggests that anticonvulsant activity of these substances does not require the formation of a common intermediate hydantoin or phenylacetylurea.

Submitted on June 21, 1950






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Copyright © 1950 by the American Society for Pharmacology and Experimental Therapeutics.