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Journal of Pharmacology And Experimental Therapeutics, Vol. 100, Issue 2, 141-145, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

AN ESTIMATION OF THE ACTIVITY OF ANALGETIC MATERIALS

D. D. Bonnycastle 1 and C. S. Leonard 1

1 Department of Pharmacology, Yale University, New Haven, Conn.

1. A relatively simple procedure is described for the estimation of the activity of analgetic drugs, utilizing the rat as the test animal.

2. The method will discriminate between weak analgetic drugs, like aspirin, and more active members of the analgetic group, like morphine.

3. In discussing the interpretation of results the data from such experiments may be treated either as a graded response or a quantal one. The estimations of activity obtained from these two different treatments are not identical.

Submitted on June 6, 1950






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